Figure 4. PP2A is involved in the cross-regulation between the Akt and p38 pathways.

Figure 4

PP2A is involved in the cross-regulation between the Akt and p38 pathways. A) Expression of phospho-Akt and -p38 in stable E1A-expressing or parental MDA-MB-231 cells that were serum-starved for 24 hours before exposure to 20.0 μM SB203580, a specific p38 inhibitor. B) Repression of p38 activity by IPTG-inducible DN-p38 enhances Akt phosphorylation and abrogates E1A-mediated sensitization to paclitaxel in E1A-expressing cells in the presence of 5 μM IPTG for 24 hours. C) Regulation of PP2A phoaphatase activity by IGF-1, wortmannin, and TNF-α in MDA-MB-231 cells. D) PARP cleavage and Akt and p38 phosphorylation in MDA-MB-231 cells after exposure to IGF-1, wortmannin, and TNF-α. WORT: wortmannnin; PD: PD98058; Flag: anti-Flag tag. B and C-D) Adapted with permission from reference 37 (Liao Y, Hung MC. Mol Cell Bio 2003; 23:6836) and reference 152 (Liao Y, Hung MC. Cancer Res 2004; 64:5938), respectively.

From: Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story

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