Table 4Effects of thermal component of fever on innate and adaptive immunity

Immune Response≤39°C≥40°CAnimal StudiesHuman StudiesRef.
Chemotaxis and emigration into inflamed or tumor tissueXX97, 129
PMN numbersXX97
133
Phagocytosis↑(↑++)XX97
(free radicals++)X129**
(↑++)X132
NK cells↓↓X112
↓↓X116
T-CellsCD3 ≈≥X107
CD4X107
X121
CD4/CD8X107
≈≥X121
B CellsX107
DCsX186, 194
HSPs↑↑XX223

↑= increased response; ↓= decreased response; PMN= polymorphonuclear leucocytes; CTLs= cytotoxic lymphocytes; **Not true for all bacterial species; and antibodies secretion is increased for a beneficial effect on T helper Cells; ↑+= means increased response in presence of a biological response modifier; ≈= No variations.

From: Effects of Local and Whole Body Hyperthermia on Immunity

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