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Table 2Published studies showing efficacy of metalloporphyrin antioxidant mimetics

Vitro ModelsCell TypeCompoundReference
Cytoxicity
Paraquatbovine endothelialMnTBAP76
rat neuronalMnTBAP77
Pyocyaninhuman epithelialMnTM-4-PyP95
Hydrogen Peroxidehuman endothelialMnTM-4-PyP57
MnTBAP
mouse fibroblastMnTBAP79
DoxorubicinRat cardiomyocteMnTBAP96
Endotoxinmouse macrophageMnTBAP58
mouse macrophageFeTMPS97
FeTPPS
MnTPPS
mouse macrophageFeTM-4-PyP98
Peroxynitritemouse macrophageMnTBAP58
mouse macrophageMnTBAP99
FeTBAP
mouse macrophageFeTMPS97
FeTPPS
FeTM-4-PyP
MNDArat neuronalMnTBAP77
Kainaterat neuronalMnTBAP77
Oxygen/Glucose Deprivationrat neuronalMnTBAP74
MnTE-2-PyP
Selective Tumor Cellvarious tumor cell linesFeTM-4-PyP100
Cyototoxicity
Neutrophil-MediatedlymphocyteMnTBAP101
Apoptosis
Staurosporinrat neuronalMnTBAP102
Ceramide
BDNF-withdrawalrat neuronalMnTBAP103
Zn-Deficient SOD1rat neuronalMnTBAP104
6-Hydroxydopaminemouse neuronalMnTBAP105
Cytokine-Inducedrat myocytesMnTBAP106
T-cell Receptor-Mediatedmouse lymphocyteMnTBAP107
mouse lymphocyteMnTBAP108
Calcium Ionophore-Inducedrat neuronalMnTBAP109
DieldrinRat PC12MnTBAP110
MPTPRat neuronalMnTBAP111
Ex Vivo Models System Compound Reference
Cardiac Hypertrophyiso guinea pig heartMnTM-4-PyP112
Long Term Potentiationrat hippocampal slidesMnTBAP113
(Memory)MnTM-4-PyP
Nitric oxide neurotransmissionbovine retractorMnTM-4-PyP114
penis muscle
Vessel RelaxationApo E KO mouse aortaMnTBAP115
Apo E KO mouseMnTBAP116
carotid arteries
Endotoxin-Induced VascularRat aortaMnTBAP99
Hyporeactivity
Endotoxinmouse peritonealMnTBAP117
macrophages
mouse peritonealMnTBAP99
macrophages
In Vivo Models Species Compound Reference
Lung
Paraquat-Induced InjurymiceMnTBAP78
Carregeenin PleuryratMnTBAP118
Bleomycin-Induced FibrosismiceMnTBAP70
Radiation-Induced FibrosisratsMnTE-2-PyP90
Cigarette Smoke-Induced InjuryratsMnTDE-1,3-Imp91
Asthma, Antigen-InducedmiceMnTE-2-PyP92
Central Nervous System
Methamphetamine-InducedFeTM-4-PyP119
Hyperthermia
Kainate-Induced SeizuresratsMnTBAP120
Cerebral VasoconstrictionAmyloid Tg miceMnTBAP121
A-b(1-40) Induced CerebralmiceMnTBAP122
Vasoconstriction
Spinal Cord InjuryratsMnTBAP123
Ischemia Brain InjuryratsMnTE-2-PyP88
mice
ratsMnTE-2-PyP75
miceMnTDE-1,3-ImP
Liver
SteatosisSOD2 KO miceMnTBAP124
Acetaminophen-InducedmiceMnTBAP125
Injury
Fas-Mediated AcutemiceMnTBAP126
Injury
Cardiovascular
CardiomyopathySOD2 KO miceMnTBAP124
Zymosan-Induced ShockratsMnTBAP127
Nitrate toleranceratsMnTBAP128
joint
Carregeenin Paw EdemaratMnTBAP129
Gastrointestinal
Acetic Acid-Induced ColitisratsMnTEGP69
Endocrine
Diabetes(T-cell-mediated)miceMnTE-2-PyP94
Renal
Sepsis — LPS InjurymiceMnTE-2-PyP130

From: Development of Manganic Porphyrin Mimetics of Superoxide Dismutase Activity

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