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Figure 1. Assembly of Microfibrils Involves Many Steps.

Figure 1

Assembly of Microfibrils Involves Many Steps. After secretion of monomeric fibrillin, early assembly events takes place within minutes to hours and include for example disulfide-bond formation. After a few days (intermediate stages) a typical fibrillin network can be monitored by indirect immunofluorescence (green fibrillin network versus red cell nuclei). It takes a few weeks (late stages) until “beads-on-a-string” microfibrils can be extracted from cell cultures. Mature microfibrils in tissue probably take even longer (months) to form and typically appear as bundles. The beaded structure is often not visible in tissue microfibrils. Images are shown in different magnifications.

From: Assembly of Microfibrils

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