FIGURE 7.8. Anterograde and transneuronal transfer of WGA to postsynaptic neurons located in deep laminae of the spinal cord (A) and in the dorsal column nuclei (B) in NPY-ZW mice.

FIGURE 7.8

Anterograde and transneuronal transfer of WGA to postsynaptic neurons located in deep laminae of the spinal cord (A) and in the dorsal column nuclei (B) in NPY-ZW mice. In NPY-ZW animals, most WGA+ afferents terminate in the medial part of deep laminae of the spinal cord and in the nucleus gracilis ipsilateral to the sciatic nerve section, which is consistent with the projection pattern of myelinated sensory neurons. Even after long survival times, we did not see an expansion of the WGA terminal field into the superficial dorsal horn, indicating that there is limited if any sprouting of these afferents after nerve injury. Scale bar 100 μm in A, 50 μm in B.

From: Chapter 7, Transgenic Mouse Models for the Tracing of “Pain” Pathways

Cover of Translational Pain Research
Translational Pain Research: From Mouse to Man.
Kruger L, Light AR, editors.
Boca Raton, FL: CRC Press; 2010.
Copyright © 2010 by Taylor and Francis Group, LLC.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.