TABLE 16.2Concentration of Atenolol, Morphine, and Oxycodone in the Plasma, Spinal Cord, and Brain of Perfused versus Non-Perfused Animals

AtenololMorphineOxycodone
Plasma cone (ng/ml)8207 ± 14821157 ± 384664 ± 47
Spinal cord (ng/g)212 ± 98443 ± 1342332 ± 466
Brain (ng/g)105 ± 28214 ± 461481 ± 363
(Perfused) plasma cone (ng/ml)7010 ± 9841217 ± 450582 ± 111
Perfused spinal cord (ng/g)129 ± 68224 ± 681295 ± 397
Perfused brain (ng/g)62 ± 12222 ± 661374 ± 332
(B) Plasma/Tissue Ratio for Concentration of Atenolol, Morphine, and Oxycodone of Perfused versus Non-Perfused Animals
AtenololMorphineOxycodone
Spinal cord: plasma ratio0.0300.3663.512
Brain: plasma ratio0.0150.2282.230
Perfused Spinal cord: plasma ratio0.0160.1952.225
Perfused brain: plasma ratio0.0080.1862.360

Note: All compounds were administered i.p. (atenolol 10 mg/kg, morphine 10 mg/kg, and oxycodone 5 mg/kg) and samples were taken 30 minutes post dosing.

From: Chapter 16, Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs

Cover of Translational Pain Research
Translational Pain Research: From Mouse to Man.
Kruger L, Light AR, editors.
Boca Raton, FL: CRC Press/Taylor & Francis; 2010.
Copyright © 2010 by Taylor and Francis Group, LLC.

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