FIGURE 5.1. Schematic of the four G-protein coupled receptors targeted by endogenous and exogenous cannabinoids/vanilloids and some of their cellular targets.

FIGURE 5.1

Schematic of the four G-protein coupled receptors targeted by endogenous and exogenous cannabinoids/vanilloids and some of their cellular targets. Abbreviations: AC, adenylyl cyclase; Akt, serine/threonine protein kinase; BK, large conductance Ca2+-activated K+ channel; cAMP, cyclic adenosine 5’-monophosphate; ERK, extracellular signal-regulated protein kinase; IR, inwardly rectifying; c-JNK, c-Jun N-terminal kinase; NFAT, nuclear factor of activated T cell; PI3K, phosphatidylinositol 3-kinase; PKA, protein kinase A; PLC, phospholipase C; ROCK, Rho-associated protein kinase.

From: Chapter 5, Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States

Cover of Translational Pain Research
Translational Pain Research: From Mouse to Man.
Kruger L, Light AR, editors.
Boca Raton, FL: CRC Press; 2010.
Copyright © 2010 by Taylor and Francis Group, LLC.

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