FIGURE 10. Isometric tension recording in an isolated blood vessel.


Isometric tension recording in an isolated blood vessel. An arterial ring is studied in an organ chamber filled with thermostated and oxygenated physiological salt solution. The inset shows recording traces of an experiment reproducing the seminal observation first made by Furchgott and Zawadzki in 1980 [496]. Isolated rings of canine coronary artery with and without endothelium are contracted with prostaglandin F (PGF). The addition of acetylcholine produces a concentration-dependent relaxation only in the ring with a preserved endothelial lining.

From: Chapter 4, Endothelium-Dependent Regulation of Vascular Tone

Cover of The Endothelium
The Endothelium: Part 1: Multiple Functions of the Endothelial Cells—Focus on Endothelium-Derived Vasoactive Mediators.
Félétou M.
San Rafael (CA): Morgan & Claypool Life Sciences; 2011.
Copyright © 2011 by Morgan & Claypool Life Sciences Publishers.

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