FIGURE 3-11. Schematic of H. pylori variation in a single host.

FIGURE 3-11Schematic of H. pylori variation in a single host

The genomes of H. pylori cells are highly plastic, subject to point mutation and intra- and intergenomic variation. A model is proposed in which related microbial individuals, a quasispecies, compete with one another in a microniche. Multiple quasispecies may compete or recombine. Local selection determines the population structure in that niche, and by competing and cooperating, populations from adjacent niches influence the overall H. pylori composition.

SOURCE: Blaser (2005).

From: 3, The Ecology of Pathogenesis

Cover of Ending the War Metaphor
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary.
Institute of Medicine (US) Forum on Microbial Threats.
Washington (DC): National Academies Press (US); 2006.
Copyright © 2006, National Academy of Sciences.

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