Table A3Criteria pertaining to relevance and modifying factors

Number of Studies (for Each Relevant Outcome)Disease CourseOutcome Subjectivity (can Knowledge of Intervention Group Affect Outcome)Potential for Unmeasured ConfoundersDegree of RelevanceFrequency of Outcome OccurrenceFeasibilityEthical ConsiderationsMinimum Time Needed to Evaluate Intervention EffectIs outcome a Harm of intervention?Concomitant Interventions or Processes of Care Changed Over TimePossibility of Substantial Carryover Effect if Interventions Given SequentiallyWill Meta-analysis be Performed?Degree of Similarity Among Different Studies (Participants, Interventions)Degree of Similarity Among Patients who did and did not Provide Data
Study participant characteristics are sufficiently similar to the participants specified in the Key Question (e.g., adults vs. children)[check]
Interventions (both treatment and comparator) sufficiently similar to the interventions specified in the Key Question[check]
Setting characteristics are sufficiently similar to the setting specified in the Key Question (e.g., inpatient vs. outpatient)[check]

From: Appendix A, Tabulation of Inclusion Criteria and Modifying Factors

Cover of A Framework for "Best Evidence" Approaches in Systematic Reviews
A Framework for "Best Evidence" Approaches in Systematic Reviews [Internet].
Treadwell JR, Singh S, Talati R, et al.

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