Evidence Table 11Cerebral palsy outcomes in KQ3

RefidOutcomeTime of Outcome MeasureStudy ArmN (Participants Measured)Number of Participants with Outcome—n (%)Relative Effect (95% CI)Adjusted Relative Effect (95% CI)Adjustments
Bennett, 20011Moderate / Severe CP18 to 22 monthsControl142 (14.3)
iNO70 (0)
Hintz SR, 20072Moderate / Severe CP3 yearsControl10211 (11)P-value; 0.11
RR: 1.85 (0.93-3.71)
P-value: Model #1: 0.0453;
Model #2: 0.048
RR: Model #1: 2.01 (1.01-3.98);
Model #2 2.41 (1.01-5.75)
Model #1: adjusted for BWt, center, sex, and OI entry criterion, birth weight,
Model #2: adjusted for BWt, center, OI entry criterion, sex, BPD, IVH gr 3 or 4 or PVL, length of iNO exposure, postnatal steroids
iNO9018 (20)
Huddy, 20083Mild CP4-5 yearsiNO164 (25)
Control226 (27.3)
Moderate / Severe CP4-5 yearsControl162 (12.5)
iNO223 (13.6)
Mestan KK, 20054Any CP25.2+/-8.4 months corrected age
24.9+/-7.9 months corrected age
Control687 (10)P-value: 0.78
iNO706 (9)
Tanaka, 20075Any CP3 yearsControl157 (46.7)
iNO162 (12.5)
Van Meurs, 20076Moderate/Severe CP18-22 monthsControl08 (0)
iNO09 (0)
Walsh, 20107Moderate / Severe CP2 yearsControl23412 (5.1)RR: 1.23 (0.59-2.55)
24.9+/-7.9 months corrected ageiNO24315 (6.2)

CI: Confidence Interval, CP: Cerebral Palsy, iNO: Inhaled Nitric Oxide, OI: Oxygenation Index, RR: Risk Ratio

From: Appendix E, Evidence Tables

Cover of Inhaled Nitric Oxide in Preterm Infants
Inhaled Nitric Oxide in Preterm Infants.
Evidence Reports/Technology Assessments, No. 195.
Allen MC, Donohue P, Gilmore M, et al.

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