CID/ML#Target NameIC50/EC50 (nM) [SID, AID]Anti-target Name(s)IC50/EC50 (μM) [SID, AID]Fold SelectiveSecondary Assay(s) Name: IC50/EC50 (nM) [SID, AID]
3245059/ML147HPGD141.3nM [SID-87550717, AID: 2429]ALDH1A> 57μM [SID-4251360, AID: 1030]> 2000-foldHPGD-deltaTm 12.2°C, [SID-87550717; AID: 2427]
3243760/ML148HPGD56.2nM [SID-87550718, AID: 2429]HADH2; HSD17β> 57μM [SID-4249877; AID-886; 893]> 1000-foldHPGD-deltaTm 7.3°C, [SID-87550718; AID-2427]
2331284/ML149HPGD89nM [SID-87550716, AID-2429]HADH2; HSD17β> 57μM [SID-3717642; AID-886; 893]> 1000-foldHPGD-deltaTm 10.5°C, [SID-87550716; AID-2427]

From: Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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