Table 4Colorectal cancer epidemiology studies

Proposed MechanismReferences
DNA repair polymorphisms90,166,185–234
Hyperproliferation of rectal mucosa141,235
Colonic microbial metabolism resulting in the generation of acetaldehyde55,56
Cytochrome P450 polymorphism236–240
Alcohol dehydrogenase and acetaldehyde dehydrogenase polymorphism19,241–252
Changes in levels of insulin-like growth factor253–256
Impact of C-reactive protein and Inflammation257,258
Methylenetetrahydrofolate reductase polymorphism/Dietary/Vitamins189,259–263
Other types of polymorphism and mechanisms259,264–294

From: 3, Results

Cover of Alcohol Consumption and Cancer Risk
Alcohol Consumption and Cancer Risk: Understanding Possible Causal Mechanisms for Breast and Colorectal Cancers.
Evidence Reports/Technology Assessments, No. 197.
Oyesanmi O, Snyder D, Sullivan N, et al.

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