Table C-3KQ1c: Diagnostic sensitivity and specificity of TPMT determinations – patient and study characteristics, part 2

StudyUnderlying disease(s)

Age group
Age (years)

mean (range) (unless otherwise noted)
Females (%)Number analyzedNumber of dropouts, withdrawals and untested participantsTPMT Activity: Number with non-interpretable test resultsGenotyping: Number with non-interpretable test results
Ansari, 200828IBD

Adults
40.3 (18 – 80)5419223NRNR
Ansari, 200229IBD

Adults
4446400NRNR
Gardiner, 200830IBD

Adult
39.2 (35.4– 42.9)51689NRNR
Haglund, 200431IBD

Mixed
38 (12–61)4330000
Hindorf, 200632IBD

Adults
28 (18–42) (median)4752NRNRNR
Hindorf, 200433IBD

Adults
36 (18–63)4755600
Langley, 200234AIH

Mixed
45 (13–72) (median)745319NRNR
Lindqvist, 200635IBD

Adults
40.5 (18–76)4760NANRNR
Marinaki, 200336IBD

NR
NRNR85NRNRNR
Okada, 200537SLE

NR
NRNR55NRNRNR
Schwab, 200238IBD

Adults
41 (17–71) (median)5293NRNRNR
Snow, 199539Autoimmune dermatologic conditions

Adults
NR (26–88)39262NRNR
Stassen, 200940Anti-neutrophil cytoplasmic antibody associated vasculitis

NR
NRNR1080NRNR
Stocco, 200541IBD

Mixed
14.2 (0.8–38.8) (median)5128NRNRNR
Stocco, 200442IBD

Mixed
16.4 (4–38)4527NRNRNR
von Ahsen, 200543IBD

Adults
36 (SD 11.6)5671000
Winter, 200744IBD

NR
4546130141414
Newman, 201045Majority of IBD patients

Adults
425033311NRNR
Hindorf, 201046Autoimmune hepatitis

Adults
55 (35–67)802299NR0

Abbreviations: AIH = autoimmune hepatitis; IBD = inflammatory bowel disease; NR = not reported; SD = standard deviation; SLE = systemic lupus erythematosus; TPMT = thiopurine methyltransferase.

From: Appendix C, Evidence Tables

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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