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Bennett WL, Wilson LM, Bolen S, et al. Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Mar. (Comparative Effectiveness Reviews, No. 27.)

Cover of Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update

Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update [Internet].

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Appendix ETallies for Comparisons Not Included in Review

Main interventionComparatorNumber of studies
MetforminAcarbose3
MetforminAny insulin3
MetforminPlacebo or any non-drug intervention21
MetforminMetformin + GLP-1 agonist5
MetforminMetformin + insulin3
ThiazolidinedioneAcarbose1
ThiazolidinedionePlacebo or any non-drug intervention38
SulfonylureaAcarbose6
SulfonylureaPlacebo or any non-drug intervention18
DPP-4 inhibitorPlacebo or any non-drug intervention9
MeglitinidesPlacebo or any non-drug intervention10
GLP-1agonistPlacebo or any non-drug intervention1
Metformin + thiazolidinedioneThiazolidinedione + DPP-4inhibitor3
Metformin + thiazolidinedioneThiazolidinedione + GLP-1agonist1
Metformin + thiazolidinedioneSulfonylurea + meglitinides1
Metformin + sulfonylureaThiazolidinedione + basal insulin1
Metformin + sulfonylureaSulfonylurea + basal insulin2
Metformin + GLP-1 agonistThiazolidinedione + GLP-1agonist1
Metformin + GLP-1 agonistSulfonylurea + GLP-1agonist1
Metformin + basal insulinSulfonylurea + basal insulin2
Metformin + premixed insulinSulfonylurea + premixed insulin1
Metformin + premixed insulinMeglitinides + premixed insulin1

Additionally, our team attempted to tally, but found no studies evaluating the following comparisons:

  • metformin versus colesevalam
  • meglitinides versus acarbose
  • combination of metformin and either thiazolidinediones, meglitinides, sitagliptin, or premixed insulin versus combinations of thiazolidinedione and either sitagliptin, exenatide, basal insulin, or premixed insulin
  • combination of metformin and thiazolidinedione versus a combination that contains either a sulfonylurea, meglitinides, or sitagliptin and either a meglitinides, sitagliptin, exenatide, basal insulin, or premixed insulin
  • combination of metformin and sulfonylurea versus combinations of thiazolidinedione and either sitagliptin, exenatide, or premixed insulin
  • combination of metformin and sulfonylurea versus a combination of sulfonylurea and either meglitinides, sitagliptin, exenatide, or premixed insulin
  • combination of metformin and sulfonylurea versus a combination that contains either a meglitinides or sitagliptin and either a sitagliptin, exenatide, or premixed insulin
  • combination of metformin and a basal insulin versus a combination of thiazolidinedione and either sitagliptin, exenatide, basal insulin, or premixed insulin
  • combination of metformin and basal insulin versus a combination that contains either a meglitinides or sitagliptin and either a sitagliptin, exenatide, or premixed insulin
  • combination of thiazolidinedione and either sulfonylurea, meglitinides, sitagliptin, or exenatide versus a combination of thiazolidinediones and either meglitinides, sitagliptin, exenatide, basal insulin, or premixed insulin
  • combination of sulfonylurea and either meglitinides, sitagliptin, or exenatide versus a combination of sulfonylureas and either sitagliptin, exenatide, basal insulin, or premixed insulin
  • combination of meglitinides and either sitagliptin or exenatide versus a combination of meglitinides and either exenatide, basal insulin, or premixed insulin
  • combination of sitagliptin and exenatide versus a combination of sitagliptin and either basal insulin or premixed insulin
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