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Table 3Binding affinity to the XIAP-BIR1/2 and BIR3 domains for representative examples

IDStructurePubChem CIDPubChem SIDBIR 1/2 IC50 (μM)BIR3 IC50 (μM)
MLS-0391057
Image ml183fu2.jpg
44176336851641672.014.3
MLS-0412059
Image ml183fu3.jpg
44176342851641703.9>100
MLS-0391058
Image ml183fu4.jpg
44176338851641686.0167.9
MLS-0412062
Image ml183fu5.jpg
44176344851641714.9>100
MLS-0391056
Image ml183fu6.jpg
44176334851641664.7132.5
MLS-0412053
Image ml183fu7.jpg
44176340851641692.2108.6
MLS-0412114
Image ml183fu8.jpg
44176346851641721.8102.7

From: Antagonists of IAP-family anti-apoptotic proteins - Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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