Table 9Study characteristics and effect sizes of trials indicating a better sleep profile with nefazodone than fluoxetine

StudySample sizeComparisonEffect measurep-valueComments
Better sleep profile with nefazodone
Rush et al. 1998118125FluoxetineSignificantly greater improvements from baseline for nefazodone on HDRS Sleep Disturbance Factors, IDS-C, and IDSR Total Sleep factorsP<0.05Pooled analysis of 3 identical studies assessing sleep quality

Abbreviations: RRR, Relative Risk Reduction; RD, Risk Difference; NNT, Number Needed to Treat

From: Results

Cover of Drug Class Review: Second-Generation Antidepressants
Drug Class Review: Second-Generation Antidepressants: Final Update 5 Report [Internet].
Gartlehner G, Hansen RA, Reichenpfader U, et al.
Portland (OR): Oregon Health & Science University; 2011 Mar.
Copyright © 2011 Oregon Health & Science University.

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