Line graph depicting the decline in number of new molecular entities per dollar expended compared to 1970–1975. A >90% decline was noted by 2002.

FIGURE 1-1Normalized new molecular entity output per dollar expended

SOURCE: Booth and Zemmel, Nature Reviews in Drug Discovery, 2004.

From: 1, Introduction

Cover of Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development
Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development: Workshop Summary.
Institute of Medicine (US) Roundtable on Translating Genomic-Based Research for Health.
Washington (DC): National Academies Press (US); 2011.
Copyright © 2011, National Academy of Sciences.

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