FIGURE 4. Ultrastructure of acinar and duct cells of the exocrine pancreas.


Ultrastructure of acinar and duct cells of the exocrine pancreas. The pancreatic acinar cell has prominent basally located rough endoplasmic reticulum for synthesis of digestive enzymes (and other proteins) and apically located zymogen granules for storage and secretion of digestive enzymes. The zymogen granules undergo exocytosis with stimulation of secretion. The secretion is into the lumen of the acinar formed by the apical surfaces of the acinar cells with their projecting microvilli. Not visualized because of the relatively low magnification are the subapical actin network, the tight junctions and the gap junctions. Pancreatic duct cells contain abundant mitochondria for energy generation needed for its ion transport functions. The ductal cells also project microvilli into the luminal space. Adapted from Gorelick F, Pandol, SJ, Topazian M. Pancreatic physiology, pathophysiology, acute and chronic pancreatitis. Gastrointestinal Teaching Project, American Gastroenterologic Association. 2003.

From: Anatomy

Cover of The Exocrine Pancreas
The Exocrine Pancreas.
Pandol SJ.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2011 by Morgan & Claypool Life Sciences.

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