FIGURE 13.3. Cholinergic muscarinic receptors play a major role in food intake and enkephalin gene expression.

FIGURE 13.3

Cholinergic muscarinic receptors play a major role in food intake and enkephalin gene expression. A single infusion of scopolamine into the Acb reduces food intake by almost half over the following 24 h period. This behavioral effect is associated with a significant downregulation of striatal PPE mRNA, but does not influence levels of PPD mRNA. Note the quantitatively similar reduction in PPE expression compared to that following food access in Figure 13.2. Hypothalamic NPY is increased by scopolamine treatment, reflective of negative energy balance. Asterisks indicate significant difference between groups or significant change in gene expression. (Adapted from Kelley, A.E. et al., J. Comp. Neurol., 493, 72, 2005.)

From: Chapter 13, Control of Fat Intake by Striatal Opioids

Cover of Fat Detection
Fat Detection: Taste, Texture, and Post Ingestive Effects.
Montmayeur JP, le Coutre J, editors.
Boca Raton (FL): CRC Press; 2010.
Copyright © 2010, Taylor & Francis Group, LLC.

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