Figure 2.4. Model of platelet integrin αIIbβ3 (GPIIb/IIIa), and conformational changes induced following activation.

Figure 2.4

Model of platelet integrin αIIbβ3 (GPIIb/IIIa), and conformational changes induced following activation. The inactive “V”-shaped compact form is shown on the left. Binding of a ligand results in extension of the molecule into its active state (middle panel), and subsequent clustering of GPIIb/IIIa molecules (right panel). According to the model, these states exist in equilibrium. From reference [53], with permission.

From: Chapter 2, General Characteristics of Platelets

Cover of Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis
Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis.
Rumbaut RE, Thiagarajan P.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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