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Cover of Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis

Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis

and .

Michael E. DeBakey VA Medical Center and Baylor College of Medicine
San Rafael (CA): Morgan & Claypool Life Sciences; .

Abstract

Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.

Copyright © 2010 by Morgan & Claypool Life Sciences.
Bookshelf ID: NBK53450PMID: 21452436
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