FIGURE 9.1. Vicious cycle of inflammation and coagulation.


Vicious cycle of inflammation and coagulation. Inflammation induces a variety of changes in ECs, leukocytes, and platelets, which promote the creation of a procoagulant, prothrombotic surface on the vessel wall (upper). Activation of the coagulation cascade, on the other hand, can elicit changes that promote inflammation (lower). The net result is that inflammation and coagulation/thrombosis are intimately linked processes wherein each process propagates and intensifies the other.

From: Chapter 7, Leukocyte–Endothelial Cell Adhesion

Cover of Inflammation and the Microcirculation
Inflammation and the Microcirculation.
Granger DN, Senchenkova E.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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