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Cover of Advances in the Neuroscience of Addiction

Advances in the Neuroscience of Addiction, 2nd edition

Frontiers in Neuroscience

Editors: Cynthia M Kuhn and George F Koob.

Editor Information

Editors: Cynthia M Kuhn1 and George F Koob2.

1 Duke University Medical Center, North Carolina
2 Scripps Research Institute, California
Boca Raton (FL): CRC Press; .
ISBN-13: 978-0-8493-7391-6

Promising Approaches to Understanding Addiction Mechanisms

Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by a distinguished international team of contributors who are authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention.

The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enables researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior.

The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.


This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint.

Copyright © 2010 by Taylor and Francis Group, LLC.
Bookshelf ID: NBK53356PMID: 21656974
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