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Figure 6.5. Model of myogenic autoregulation.

Figure 6.5

Model of myogenic autoregulation. Model assumes that resistance vessels have a sensor in series with the contractile element that responds to changes in wall tension as defined by the Law of LaPlace (tension equals the transmural pressure times the radius, T = Pr). The model addresses a theoretical issue for myogenic autoregulation, i.e., if the arterial wall is stretched by an increase in pressure, the muscle cannot simply contract back to its original length, since that would return the vessel to its original radius, resistance would be unchanged, and flow would increase. For flow to remain constant despite an increase in pressure, the muscle fibers need to shorten to less than their pre-stretched length, so that the radius is less than control and resistance increases. With moderate feedback gain, the model predicts autoregulatory flow behavior. However, if the gain is too high, the model predicts “super-regulation” where flow increases in response to decreased perfusion pressure35,38. Reproduced with permission from American Physiological Society.

From: Chapter 6, Local control of ocular blood flow

Cover of The Ocular Circulation
The Ocular Circulation.
Kiel JW.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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