Figure 6.24. Inhibition of neural control by ganglionic blockade with hexamethonium causes a modest downward shift in the pressure-flow relationship but flow remains pressure-independent over a wide pressure range, indicating the autoregulatory behavior is locally mediated.

Figure 6.24

Inhibition of neural control by ganglionic blockade with hexamethonium causes a modest downward shift in the pressure-flow relationship but flow remains pressure-independent over a wide pressure range, indicating the autoregulatory behavior is locally mediated. Non-selective NOS inhibition with L-NAME elicits a marked downward shift in the pressure-flow relationship that is largely reversed by non-selective endothelin antagonism indicating significant roles of nitric oxide and endothelin in choroidal blood flow regulation75. Reproduced with permission from Experimental Eye Research, Elsevier.

From: Chapter 6, Local control of ocular blood flow

Cover of The Ocular Circulation
The Ocular Circulation.
Kiel JW.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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