Table 4.2Endothelial-associated genes in human placental artery and vein endothelial cells

Gene NameFull NameFunction
Hey-2Hairy/enhancer-of-split related with YRPW motif 2Locate in the nucleus to interact with a histone deacetylase to repress transcription
Connexin40Gap junction protein, delta 4 (41kDa)Involved in the formation of gap junction and intracellular conduits that connect the cytoplasm of connecting cells
Connexin37Gap junction protein, delta 4 (37 Kda)Component of gap junction, provide channels for the diffusion of low molecular weight material from cell to cell
MGPMatrix Gla proteinAn inhibitor of arterial wall and cartilage calcification
NOS3Nitric oxide synthase 3 (endothelial cells)Synthesis of nitric oxide
DeppChromosome 10 open reading frame 10Production of this gene leads to phosphorylation and activation of transcription factor ELK1
Angpt2Angiopoietin 2Antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK)
ESM1Endothelial cell-specific molecule 1Might play a role in endothelium-dependent pathological disorder
Ephin B1Ephin ligand B1Transduces signals to activate integrin- mediated migration, attachment and angiogenesis
EphinB2Ephin ligand B2Involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions
Flt-1Fms-related tyrosine kinase 1 (VEGF-R1)Binding to VEGF-A, VEGF-B and PlGF and playing important role in vasculogenesis and angiogenesis
KDR/flk-1Kinase insert domain receptor (VEGF-R2)Main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting
Edg1Sphingosine-1-phosphate receptorInvolved in endothelial differentiation and activation, and cell-cell adhesion
Notch 4Notch homologCell fate decision
MDG1DnaJ (Hsp40) homolog, subfamily B, memberPromote the turnover of unfolded surfactant protein C (unfolded protein response)
GremlinGremlinThis gene encodes a member of the BMP antagonist family. It regulates organogenesis, body patterning and tissue differentiation
MEOX2Mesenchymal homeobox 2Play essential role in embryogenesis, development, and cell differentiation, transcription and DNA regulation
DSC54Stem cell protein DSC54A mesenchymal stem cell marker
Nrp-1Neuropilin-1Plays versatile role in angiogenesis, cell survival, migration and invasion
Nrp-2Neuropilin 2Interact with VEGF and play a role in vascular development
EDG2Lysophosphatidic acid receptor 1Member of G protein-grouped receptor superfamily, mediates diverse biologic functions, including proliferation, platelet aggregation, smooth muscle cell contraction, and chemotaxis
EndoglinEndoglinA major glycoprotein on endothelial cells. It binds to TGFβ1 and TGFβ3 with high affinity
EPAS1endothelial PAS domain protein 1Encodes a transcription factor involved in induction genes regulated by oxygen

From: Chapter 4, Cell Types of the Placenta

Cover of Vascular Biology of the Placenta
Vascular Biology of the Placenta.
Wang Y, Zhao S.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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