NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Cover of FGF Signalling in Vertebrate Development

FGF Signalling in Vertebrate Development

and .

Author Information

1 and 2.

1 University of York
2 University of York
San Rafael (CA): Morgan & Claypool Life Sciences; .

Abstract

The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right–left asymmetry.

Copyright © 2010 by Morgan & Claypool Life Sciences.
Bookshelf ID: NBK53164PMID: 21452439DOI: 10.4199/C00011ED1V01Y201004DEB002
PubReader format: click here to try

Views

Other titles in this collection

Related information

Related citations in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...