FIGURE 11. FGF10 signals to drive branching morphogenesis in the developing mouse lung.

FIGURE 11

FGF10 signals to drive branching morphogenesis in the developing mouse lung. FGF10 is present in the mesenchyme, while FGFR2 is expressed in the epithelium. In response to FGF signals, the epithelium forms a bud and also activates the expression of Sprouty2 and Shh. Both of these gene products dampen the activity of the MAPK pathway; Shh is thought to do this by inhibiting the expression of FGF10. Turning down FGF signalling restricts the formation of buds, in this way other parts of the tubule still competent to respond to FGF will now form new buds.

From: Morphogenesis

Cover of FGF Signalling in Vertebrate Development
FGF Signalling in Vertebrate Development.
Pownall ME, Isaacs HV.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.