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Cipolla MJ. The Cerebral Circulation. San Rafael (CA): Morgan & Claypool Life Sciences; 2009.

Cover of The Cerebral Circulation

The Cerebral Circulation.

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Summary

The brain’s circulation has many unique properties that under normal conditions help maintain constant perfusion to an organ with high metabolic demands. In addition, the unique structural properties of the cerebral endothelium, including tight junctions that do not allow ions to pass freely, a low rate of transcellular transport, and very low hydraulic conductivity, help to maintain an appropriate ionic milieu for neuronal function and to control water homeostasis in an organ that has limited capacity to expand within the skull. When disrupted by trauma or disease, these important features of the cerebral circulation are lost and brain injury can occur. Although a great deal has been learned regarding the structure and function of the cerebral circulation over the past few decades, the use of transgenic animals and sophisticated imaging has and will continue to provide greater insight into cerebrovascular function and how it can be preserved to prevent brain injury.

Copyright © 2010 by Morgan & Claypool Life Sciences.
Bookshelf ID: NBK53088
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