Photomicrographs, line drawing, and radiograph presenting four images of the nature of lesions of centrilobular emphysema shown to better advantage.

Figure 7.8Details of centrilobular emphysema lesions

Source: Hogg 2004. Reprinted with permission from Elsevier, © 2004.

Note: (A) Several normal terminal bronchioles within a secondary lung lobule defined by its surrounding connective tissue septa (solid arrow) are shown for comparison with (B) the histology of a normal acinus beyond a single terminal bronchiole. (C) Line drawing from Leopold and Gough’s original (1957) description of centrilobular emphysema showing the destruction of the respiratory bronchioles, and (D) a postmortem radiograph of the dilatation and destruction of the respiratory bronchioles. AD = alveolar duct; CLE = centrilobular emphysema; RB = respiratory bronchioles; TB = terminal bronchioles.

From: 7, Pulmonary Diseases

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How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General.
Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US).

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