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Institute of Medicine (US) Forum on Neuroscience and Nervous System Disorders. CNS Clinical Trials: Suicidality and Data Collection, Workshop Summary. Washington (DC): National Academies Press (US); 2010.

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CNS Clinical Trials: Suicidality and Data Collection, Workshop Summary.

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  1. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry. 2003;8(7):646–653. [PubMed: 12874600]
  2. Beck AT, Brown GK, Steer RA. Psychometric characteristics of the scale for suicide ideation with psychiatric outpatients. Behav Res Ther. 1997;35(11):1039–1046. [PubMed: 9431735]
  3. Beck AT, Brown GK, Steer RA, Dahlsgaard KK, Grisham JR. Suicide ideation at its worst point: A predictor of eventual suicide in psychiatric outpatients. Suicide Life Threat Behav. 1999;29(1):1–9. [PubMed: 10322616]
  4. Bridge JA, Barbe RP, Birmaher B, Kolko DJ, Brent DA. Emergent suicidality in a clinical psychotherapy trial for adolescent depression. Am J Psychiatry. 2005;162(11):2173–2175. [PubMed: 16263860]
  5. Bridge JA, Greenhouse JB, Weldon AH, Campo JV, Kelleher KJ. Suicide trends among youths aged 10 to 19 years in the United States, 1996–2005. JAMA. 2008;300(9):1025–1026. [PubMed: 18768413]
  6. Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, Ren L, Brent DA. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: A meta-analysis of randomized controlled trials. JAMA. 2007;297(15):1683–1696. [PubMed: 17440145]
  7. Brown GK, Ten Have T, Henriques GR, Xie SX, Hollander JE, Beck AT. Cognitive therapy for the prevention of suicide attempts: A randomized controlled trial. JAMA. 2005;294(5):563–570. [PubMed: 16077050]
  8. Buckman S. Ways to facilitate collaboration: How and who?. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  9. Cavanagh JT, Carson AJ, Sharpe M, Lawrie SM. Psychological autopsy studies of suicide: A systematic review. Psychol Med. 2003;33(3):395–405. [PubMed: 12701661]
  10. CDC (Centers for Disease Control and Prevention) Suicide injury deaths and rates per 100,000. 2006. [accessed December 10, 2009]. http://www​.cdc.gov/injury/wisqars/index​.html.
  11. Currier D, Mann JJ. Stress, genes and the biology of suicidal behavior. Psychiatr Clin North Am. 2008;31(2):247–269. [PMC free article: PMC2710608] [PubMed: 18439448]
  12. Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR. The return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science. 1994;264(5162):1102–1105. [PubMed: 8178168]
  13. Engel GL. The biopsychosocial model and the education of health professionals. Ann N Y Acad Sci. 1978;310:169–187. [PubMed: 290321]
  14. Fawcett J, Clark DC, Scheftner WA. The assessment and management of the suicidal patient. Psychiatr Med. 1991;9(2):299–311. [PubMed: 1857765]
  15. FDA (Food and Drug Administration) Questions and answers on antidepressant use in children, adolescents, and adults: May, 2007. 2007. [accessed December 10, 2009]. http://www​.fda.gov/Drugs​/DrugSafety/InformationbyDrugClass​/ucm096321.htm.
  16. Fombonne E, Wostear G, Cooper V, Harrington R, Rutter M. The Maudsley long-term follow-up of child and adolescent depression. 2. Suicidality, criminality and social dysfunction in adulthood. Br J Psychiatry. 2001;179:218–223. [PubMed: 11532798]
  17. Galfalvy H, Huang YY, Oquendo MA, Currier D, Mann JJ. Increased risk of suicide attempt in mood disorders and tph1 genotype. J Affect Disord. 2009;115(3):331–338. [PMC free article: PMC4440550] [PubMed: 18977032]
  18. Gibbons R. CNS clinical trials: Suicidality and data collection. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  19. Gibbons R, Mann JJ. Proper studies of selective serotonin reuptake inhibitors are needed for youth with depression. CMAJ. 2009;180(3):270–271. [PMC free article: PMC2630356] [PubMed: 19188617]
  20. Gibbons R, Brown CH, Hur K, Mann JJ. Relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder. Arch Gen Psychiatry. 2009;66(12):1354–1360. [PMC free article: PMC3926811] [PubMed: 19996040]
  21. Gibbons RD, Brown CH, Hur K, Marcus SM, Bhaumik DK, Erkens JA, Herings RM, Mann JJ. Early evidence on the effects of regulators’ suicidality warnings on SSRI prescriptions and suicide in children and adolescents. Am J Psychiatry. 2007;164(9):1356–1363. [PubMed: 17728420]
  22. Goodwin F, Jamison K. Manic-depressive illness: Biopolar disorders and recurrent depression. 2nd ed. Oxford, UK: Oxford University Press; 2007.
  23. Greenhouse JB, Kaizar EE, Kelleher K, Seltman H, Gardner W. Generalizing from clinical trial data: A case study. The risk of suicidality among pediatric antidepressant users. Stat Med. 2008;27(11):1801–1813. [PMC free article: PMC2963861] [PubMed: 18381709]
  24. Guzzetta F, Tondo L, Centorrino F, Baldessarini RJ. Lithium treatment reduces suicide risk in recurrent major depressive disorder. J Clin Psychiatry. 2007;68(3):380–383. [PubMed: 17388706]
  25. Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry. 2006;63(3):332–339. [PubMed: 16520440]
  26. Harris E, Barraclough B. Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry. 1997;170:205–228. [PubMed: 9229027]
  27. Heim C, Nemeroff CB. The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biol Psychiatry. 2001;49(12):1023–1039. [PubMed: 11430844]
  28. Hill AB. The environment and disease: Association or causation? Proc R Soc Med. 1965;58:295–300. [PMC free article: PMC1898525] [PubMed: 14283879]
  29. IOM (Institute of Medicine) Reducing suicide: A national imperative. Washington, DC: The National Academies Press; 2002.
  30. Kaizar EE, Greenhouse JB, Seltman H, Kelleher K. Do antidepressants cause suicidality in children? A Bayesian meta-analysis. Clin Trials. 2006;3(2):73–90. discussion 91–98. [PubMed: 16773951]
  31. Keilp JG, Oquendo MA, Stanley BH, Burke AK, Cooper TB, Malone KM, Mann JJ. Future suicide attempt and responses to serotonergic challenge. Neuropsychopharmacology. 2008 online publication March 19. [PMC free article: PMC3055397] [PubMed: 18354392]
  32. Knox KL, Litts DA, Talcott GW, Feig JC, Caine ED. Risk of suicide and related adverse outcomes after exposure to a suicide prevention programme in the US Air Force: Cohort study. BMJ. 2003;327(7428):1376. [PMC free article: PMC292986] [PubMed: 14670880]
  33. Kovacs M, Goldston D, Gatsonis C. Suicidal behaviors and childhood-onset depressive disorders: A longitudinal investigation. J Am Acad Child Adolesc Psychiatry. 1993;32(1):8–20. [PubMed: 8428888]
  34. Laughren T. Development of Division of Psychiatry Products policy on prospective suicidality assessment in studies conducted under INDs. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  35. Lauterbach E, Felber W, Muller-Oerlinghausen B, Ahrens B, Bronisch T, Meyer T, Kilb B, Lewitzka U, Hawellek B, Quante A, Richter K, Broocks A, Hohagen F. Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: A randomised, placebo-controlled, 1-year trial. Acta Psychiatr Scand. 2008;118(6):469–479. [PubMed: 18808400]
  36. Libby AM, Orton HD, Valuck RJ. Persisting decline in depression treatment after FDA warnings. Arch Gen Psychiatry. 2009;66(6):633–639. [PubMed: 19487628]
  37. Little A. Treatment-resistant depression. Am Fam Physician. 2009;80(2):167–172. [PubMed: 19621857]
  38. Luoma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: A review of the evidence. Am J Psychiatry. 2002;159(6):909–916. [PubMed: 12042175]
  39. Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci. 2003;4(10):819–828. [PubMed: 14523381]
  40. Mann JJ. Treatment-emergent suicidal events in adolescents: Neurobiologic considerations. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  41. Mann JJ, Currier D, Stanley B, Oquendo MA, Amsel LV, Ellis SP. Can biological tests assist prediction of suicide in mood disorders? Int J Neuropsychopharmacol. 2006;9(4):465–474. [PubMed: 15967058]
  42. MHRA (Medicines and Healthcare Products Regulatory Agency) Selective serotonin reuptake inhibitor—use in children and adolescents with major depressive disorder. 2003. [accessed January 4, 2010]. http://www​.mhra.gov.uk​/home/groups/pl-p/documents​/websiteresources/con019492.pdf.
  43. Moskowitz DS, Young SN. Ecological momentary assessment: What it is and why it is a method of the future in clinical psychopharmacology. J Psychiatry Neurosci. 2006;31(1):13–20. [PMC free article: PMC1325062] [PubMed: 16496031]
  44. NIMH (National Institute of Mental Health) Results for Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. 2009. [accessed December 9, 2009]. http://www​.nimh.nih.gov​/health/trials/practical/stard/index​.shtml.
  45. Nock MK, Hwang I, Sampson N, Kessler RC, Angermeyer M, Beautrais A, Borges G, Bromet E, Bruffaerts R, de Girolamo G, de Graaf R, Florescu S, Gureje O, Haro JM, Hu C, Huang Y, Karam EG, Kawakami N, Kovess V, Levinson D, Posada-Villa J, Sagar R, Tomov T, Viana MC, Williams DR. Cross-national analysis of the associations among mental disorders and suicidal behavior: Findings from the WHO world mental health surveys. PLoS Med. 2009a;6(8):e1000123. [PMC free article: PMC2717212] [PubMed: 19668361]
  46. Nock MK, Hwang I, Sampson NA, Kessler RC. Mental disorders, comorbidity and suicidal behavior: Results from the National Comorbidity Survey Replication. Mol Psychiatry. 2009b 2009 Mar 31 [PMC free article: PMC2889009] [PubMed: 19337207]
  47. Olfson M, Marcus SC, Shaffer D. Antidepressant drug therapy and suicide in severely depressed children and adults: A case-control study. Arch Gen Psychiatry. 2006;63(8):865–872. [PubMed: 16894062]
  48. Pace WD, Cifuentes M, Valuck RJ, Staton EW, Brandt EC, West DR. An electronic practice-based network for observational comparative effectiveness research. Ann Intern Med. 2009;151(5):338–340. [PubMed: 19638402]
  49. Pandey GN, Dwivedi Y. Noradrenergic function in suicide. Arch Suicide Res. 2007;11(3):235–246. [PubMed: 17558608]
  50. Posner K. C-CASA and C-SSRS in CNS clinical trials: Development and implementation. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  51. Posner K, Oquendo MA, Gould M, Stanley B, Davies M. Columbia Classification Algorithm of Suicide Assessment (C-CASA): Classification of suicidal events in the FDA’s pediatric suicidal risk analysis of antidepressants. Am J Psychiatry. 2007;164(7):1035–1043. [PMC free article: PMC3804920] [PubMed: 17606655]
  52. Rao U, Weissman MM, Martin JA, Hammond RW. Childhood depression and risk of suicide: A preliminary report of a longitudinal study. J Am Acad Child Adolesc Psychiatry. 1993;32(1):21–27. [PubMed: 8428874]
  53. Rush A. Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR) 2009. [accessed December 11, 2009]. http:​//counsellingresource​.com/quizzes/qids-depression​/index.html.
  54. Rutz W, von Knorring L, Walinder J. Frequency of suicide on Gotland after systematic postgraduate education of general practitioners. Acta Psychiatr Scand. 1989;80(2):151–154. [PubMed: 2801163]
  55. Rutz W, von Knorring L, Walinder J. Long-term effects of an educational program for general practitioners given by the Swedish Committee for the Prevention and Treatment of Depression. Acta Psychiatr Scand. 1992;85(1):83–88. [PubMed: 1546555]
  56. Sareen J, Cox BJ, Afifi TO, de Graaf R, Asmundson GJ, ten Have M, Stein MB. Anxiety disorders and risk for suicidal ideation and suicide attempts: A population-based longitudinal study of adults. Arch Gen Psychiatry. 2005;62(11):1249–1257. [PubMed: 16275812]
  57. Stone M, Laughren T, Jones ML, Levenson M, Holland PC, Hughes A, Hammad TA, Temple R, Rochester G. Risk of suicidality in clinical trials of antidepressants in adults: Analysis of proprietary data submitted to U.S. Food and Drug Administration. BMJ. 2009;339:b2880. [PMC free article: PMC2725270] [PubMed: 19671933]
  58. Szanto K, Mulsant BH, Houck PR, Dew MA, Dombrovski A, Pollock BG, Reynolds CF. Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. J Affect Disord. 2007;98(1–2):153–161. [PubMed: 16934334]
  59. Valuck RJ. Studying suicidality: From RCTs to OCER. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection; Washington, DC. June 16.2009.
  60. Valuck RJ, Orton HD, Libby AM. Antidepressant discontinuation and risk of suicide attempt: A retrospective, nested case-control study. J Clin Psychiatry. 2009;70(8):1069–1077. [PubMed: 19758520]
  61. Weisberg HI, Hayden VC, Pontes VP. Selection criteria and generalizability within the counterfactual framework: Explaining the paradox of antidepressant-induced suicidality? Clin Trials. 2009;6(2):109–118. [PubMed: 19342462]
  62. Weissman MM, Wolk S, Goldstein RB, Moreau D, Adams P, Greenwald S, Klier CM, Ryan ND, Dahl RE, Wickramaratne P. Depressed adolescents grown up. JAMA. 1999;281(18):1707–1713. [PubMed: 10328070]
  63. Zisook S, Trivedi MH, Warden D, Lebowitz B, Thase ME, Stewart JW, Moutier C, Fava M, Wisniewski SR, Luther J, Rush AJ. Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: An examination of citalopram in the STAR*D study. J Affect Disord. 2009;117(1–2):63–73. [PubMed: 19217668]
Copyright © 2010, National Academy of Sciences.
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