TABLE 13.1

Comparison of the Biophysical Properties of Native Cold/Menthol Currents and Heterologously Expressed TRPM8

NativeTRPM8References
Temperature activation threshold27.1 ± 0.5°; 28.7 ± 2.7°25.8 ± 0.4°; 21.8 ± 0.6°[2]; [16]; [3]
Menthol EC5080 ± 2.4 μM66.7 ± 3.3 μM 101 ± 13°[2]; [30]
Current-voltage relationshipOutwardly rectifyingOutwardly rectifying[2]; [3]
Ion permeabilitiesPCa/PNa = 3.23.3; 0.97[2]; [3]
PK/PNa = 1.11.2; 1.34[2]; [3]
PCs/PK = 1.21.1[2]
PCs/PNa = N.A1.43[3]
Ion selectivityErev − Na+ = −5.1 ± 3.1mV−3.8 ± 2.4mV; −20 ± 5 mV[2]; [48]
Erev − K+ = −4.5 ± 2.0 mV0.8 ± 1.0 mV; −5.3 ± 1.5 mV[2]; [48]
Erev − NMDG = − 85.0 ± 11.5 mV[2]
Erev − Ca2+ = − 43.3 ± 4.6 mV− 77.2 ± 5.9 mV[2]
−35.2 ± 8.0 mV

From: Chapter 13, TRPM8: The Cold and Menthol Receptor

Cover of TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
Liedtke WB, Heller S, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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