FIGURE 3.5. The effect of various doses of diazepam alone (DZP; closed squares) or in combination with 5 mg/kg of flumazenil (open squares) in rats trained to discriminate 3 mg/kg of diazepam from vehicle (top figure).

FIGURE 3.5

The effect of various doses of diazepam alone (DZP; closed squares) or in combination with 5 mg/kg of flumazenil (open squares) in rats trained to discriminate 3 mg/kg of diazepam from vehicle (top figure). The bottom figure depicts the effects of various doses of DZP alone (closed squares) or in combination with 5 mg/kg (open squares) or 12 mg/kg (open circles) of flumazenil. Ordinate: Mean (n = 12) percent (± SEM) of responses on the diazepam-appropriate lever after the administration of 5 mg/kg or 12 mg/kg of flumazenil in combination with various doses of DZP. Abscissa: Diazepam drug dose plotted on a logarithmic scale. Typically, a figure of response rates would appear below this figure.

From: Chapter 3, Drug Discrimination

Cover of Methods of Behavior Analysis in Neuroscience
Methods of Behavior Analysis in Neuroscience. 2nd edition.
Buccafusco JJ, editor.
Boca Raton (FL): CRC Press; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

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