FIGURE 11.9. Prefrontal and striatal lesions both produce a marked decline in response accuracy in the operant delayed alternation test.

FIGURE 11.9

Prefrontal and striatal lesions both produce a marked decline in response accuracy in the operant delayed alternation test. The upper and lower panels illustrate choice accuracy depending on whether the previous trial was correct or incorrect. While the pre-frontal lesions induced a similar deficit on all trials irrespective of performance on previous trials, the striatal lesions induced a deficit whereby a deficit on the previous trial increased the chance of a deficit on the present trial. This is directly against an interference effect between trials and suggests a perseverative tendency of the rats with striatal lesions. Source: Data from Dunnett, S. B., Nathwani, F., and Brasted, P. J. 1999. Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats. Behav. Brain Res. 106:13–28.

From: Chapter 11, Operant Analysis of Fronto-striatal Function in Rodents

Cover of Methods of Behavior Analysis in Neuroscience
Methods of Behavior Analysis in Neuroscience. 2nd edition.
Buccafusco JJ, editor.
Boca Raton (FL): CRC Press; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.