Table 2Potency and selectivity of lead scaffolds from HTS screen

StructureSIDCIDS1P4 IC50 (nM) [AID-2332]S1P1 IC50 (µM) [AID-2351]S1P2 IC50 (µM) [AID-2354]S1P3 IC50 (µM) [AID-2349]S1P5 IC50 (µM) [AID-2350]
Image ml131fu3.jpg
87241457136329939.3>25.014.025.49.6
Image ml131fu4.jpg
87241471706322339>25.0>25.0>25.0>25.0
Image ml131fu5.jpg
87241467232869482.7>25.02.31.71.3
Image ml131fu6.jpg
8724146662177043420.3510.6100.4940.034

From: Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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