10.10.1What is the prevalence of syphilis infection in pregnant women in the UK?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Hurtig et al., 1998620139 women treated for syphilis during pregnancy and 17 children meeting the case definition of congenital syphilis from 1994 to 1997, excluding Scotland (n = 136)National survey of genitourinary medicine specialists and paediatricians; surveillanceIncidence of syphilis detected in pregnancy and congenital syphilis121 women were detected through antenatal screening: 31 had confirmed or probably congenitally transmissible syphilis (30 excluding Scotland); NNT = 18,600 and 55,700 (maximum numbers) to detect one woman needing treatment and to prevent one case of congenital syphilis, respectivelyOver the period 1994 to 1997, over 2 million women would have been screened as part of antenatal careCSS3
PHLS CDSC and PHLS Syphilis Working Group, 1998453139 women treated for syphilis during pregnancy and 17 children meeting the case definition of congenital syphilis from 1994 to 1997, excluding Scotland (n = 136)National survey of genitourinary medicine specialists and paediatricians; surveillanceMinimum overall prevalence of women considered to need treatment for syphilis in pregnancyFor England and Wales: 0.068 (95% CI 0.057 to 0.080) per 1,000 live birthsDenominators derived from routine ONS birth statistics.CSS3
Flowers and Camilleri-Ferrante, 1996452Pregnant women in East Anglia identified by screeningSurveillancePositive screening test for syphilis4–8 per million pregnanciesEstimated from 1991–1995 out of an estimated 130,000 pregnancies screened.SV3

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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