10.5.2What is the prevalence of congenital hepatitis B virus in the UK?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Ramsay et al., 1998385England and Wales from 1985 to 1996Surveillance of laboratory reported cases to PHLS communicable disease surveillance centresInfection in children (under 15 years)
Number of cases due to mother-to-child transmission
Estimated annual number of perinatal transmissions which lead to chronic carriage
Total of 173 cases reported
37/173 (21%) due to mother-to-child transmission
93/116 cases of perinatal transmission leading to carriage per year
Assumption that 80% of perinatal infections lead to chronic carriageCSS3
Derso et al., 1978382Approximately 240,000 pregnant women from antenatal clinics in West Midlands, England, from May 1974 to May 1977Serum screening using HBsAgInfants HBsAg positive beyond 3 months of ageAntigen detected in cord blood of 101/219 (46%) of 269 babies delivered
17/122 (14%) babies followed up beyond 3 months of age had persistently high titres of HBsAg; 64% were Chinese, 30% African-Caribbean and 8% Asian (0 European)
The paper states that 297 carrier mothers were discovered but in the table of ethnic distribution of mothers, only 100 mothers are accounted forCOM3

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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