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Table 11.8Alpha-fetoprotein (AFP)

Author, year, country, EL, study designNo. of women analysed, inclusion/exclusion criteria, age, gestational age at testReference standard used, incidence of PEIndex test cut-offResultsComments and conclusion
Yaron (1999)857 USA, EL II, prospective cohort study60 040,
EX: structural or chromosomal anomalies
Age n.r.
14–22 weeks
SBP ≥ 140 mmHg or DBP ≥ 90 mmHg;
presence of proteinuria,
Competitive RIA (Sanofi Diagnostics)
2.5 MoM
ST 4.3%, SP 97.4%Multiple marker screening can be used for the detection of not only fetal anomalies and aneuploidy but also for detection of high-risk pregnancy
Pouta (1998)858
Finland, EL II, population-based cohort study
IN: nulliparas
EX: multiple pregnancies, fetal defects
27.7 ± 4.5 years
15–19 weeks
BP ≥ 140/90 mmHg 6 hours apart or rise 30/15 mmHg;
Prot. ≥ 300 mg/24 hours,
Time-resolved FIA (Wallac)
2.0 MoM
ST 3%, SP 98%AFP not helpful in predicting pre-eclampsia

From: 11, Screening for clinical problems

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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