Redesigning the Clinical Effectiveness Research Paradigm: Innovation and Practice-Based Approaches
A Learning Healthcare System Workshop
IOM Roundtable on Evidence-Based Medicine
December 12–13, 2007
The National Academy of Sciences Building
2100 C Street, NW
Washington, DC 20037
Issues motivating the discussion
- Need for substantially improved understanding of the comparative clinical effectiveness of healthcare interventions.
- Strengths of the randomized controlled trial muted by constraints in time, cost, and limited applicability.
- Opportunities presented by the size and expansion of potentially interoperable administrative and clinical datasets.
- Opportunities presented by innovative study designs and statistical tools.
- Need for innovative approaches leading to a more practical and reliable clinical research paradigm.
- Need to build a system in which clinical effectiveness research is a more natural by-product of the care process.
Goal: To explore these issues, identify potential approaches, and discuss possible strategies for their engagement.
Workshop Planning Committee
Robert M. Califf, MD, Duke Clinical Research Institute, Duke University
Lynn Etheredge, George Washington University
Kim Gilchrist, MD, AstraZeneca LP
Bryan Luce, PhD, MBA, United Biosource Corporation
Jonathan Perlin, MD, PhD, MSHA, FACP, HCA Inc.
Richard Platt, MD, MS, Harvard Medical School and Harvard Pilgrim
National Academies Press (US), Washington (DC)
Institute of Medicine (US) Roundtable on Value & Science-Driven Health Care; Olsen LA, McGinnis JM, editors. Redesigning the Clinical Effectiveness Research Paradigm: Innovation and Practice-Based Approaches: Workshop Summary. Washington (DC): National Academies Press (US); 2010. Appendix A, Workshop Agenda.