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Table 2MDS Pharma Lead Profiling Screen for CID 44123653

TargetSpecies%inhibition (10 mM) CID 44123657
Adenosine A1human14
Adenosine A2human13
Adenosine A3human21
Adrenergicα1Arat6
Adrenergicα1Brat5
Adrenergicα1Chuman10
Adrenergicα2Ahuman14
Adrenergicβ1human6
Adrenergicβ2human9
Androgen (testosterone)ARrat10
Bradykinin B1human14
Bradykinin B2human−16
Calcium channel L type, benzothiazepinerat22
Calcium channel L type, dihydropyridinerat26
Calcium channel N typerat0
Dopamine D1human−2
Dopamine D2human−6
Dopamine D3human1
Dopamine D4human75
Endothelin ETAhuman0
Endothelin ETBhuman2
Epidermal Growth Factor (EGF)human5
Estrogen ERαhuman1
G protein-coupled receptor GPR 103human15
GABAA Flunitrazepam, centralrat77
GABAA Muscimol, centralrat−3
GABAB,Ahuman0
Glucocorticoidhuman3
Glutamata, Kainaterat2
Glutamate, NMDA, Agonismrat5
Glutamate, NMDA, Glycinerat5
Glutamate, NMDA, Phencydidinerat0
Histamine H1human13
Histamine H2human0
Histamine H3human−13
Imidazoline I1 Centralrat0
Interleukin IL-1mouse−3
Leukotriene, Cysteinyl CysL T1human0
Melatonin MT1human0
Muscarinic M1human2
Muscarinic M2human4
Muscarinic M3human−4
Neuropeptide YY1human5
Neuropeptide YY2human−1
Nicotinic Acetylcholinehuman−3
Nicotinic Acetylcholine, Bungarotoxinhuman13
Opiateδ (OP1, DOP)human−13
Opiateκ (OP2, KOP)human18
Opiate μ (OP3, MOP)human15
Phorbol Estermouse−6
Platelet Activating Factor(PAF)human5
Potassium Channel [KATP]hamster−6
Potassium Channel hERGhuman43
Prostanoid EPhuman10
Purinergic P2Xrabbit−2
Purinergic P2Yrat10
Rolipramrat−2
Serotonin (5-Hydroxytryptamine) 5-HTAhuman14
Serotonin (5-Hydroxytryptamine) 5-HTBhuman9
Sigmaσ1human21
Sigmaσ2rat18
Sodium Channel, Site 2rat28
Tachykinin NK1human4
Thyroid Hormonerat5
Transporter, Dopamine(DAT)human59
Transporter, GABArat16
Transporter, Norepinephrine (NET)human56
Transporter, Serotonin (5-Hydroxytryptamine) (SERT)human1

From: Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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