Table 2Calculated Property Comparison with MDDR Compounds

PropertyCID 44251556MDDR Phase IMDDR Launched
MW335.33438.98415.20
cLogP3.013.212.21
TPSA55.2097.0691.78
Hdon0.002.122.13
Hacc5.007.066.47
LogS−4.81−4.96−3.73
NrotB3.007.085.71

From: Discovery and development of the a highly selective M1 Positive Allosteric Modulator (PAM)

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