Table 3Structure and activity of analogs of 3

Image ml133fu3.jpg
CmpdCIDSIDVU#*ArKir2.1 IC50 (nM) − Manual Patch ClampKir2.1 IC50 (nM) − Ion Works
3a4424746685281105VU0404943-1S
Image ml133fu4.jpg
29013630
3b4448316885786744VU0408963-1S
Image ml133fu5.jpg
77311470
3c4448317285786747VU0126571-3S
Image ml133fu6.jpg
10608990
3d4448317185786746VU0408965-1S
Image ml133fu7.jpg
389089670
3e4448316785786743VU0408962-1S
Image ml133fu8.jpg
139014010
3f4448317685786750VU0023698-2S
Image ml133fu9.jpg
515016760
3g4448316985786745VU0408964-1S
Image ml133fu10.jpg
183024070
3h4448316685786742VU0408961-1S
Image ml133fu11.jpg
253013340
3i4448316585786741VU0408960-1S
Image ml133fu12.jpg
48109050
3j4448317385786748VU0408966-1S
Image ml133fu13.jpg
949043100
3k4448317585786749VU0408967-1S
Image ml133fu14.jpg
13880204550
3l78125087326016VU0409607-1S
Image ml133fu15.jpg
9760
3m73857487225308VU0409031-1S
Image ml133fu16.jpg
20600
3n4459387287326020VU0409677-1S
Image ml133fu17.jpg
5100
3o73856487326018VU0093214-2S
Image ml133fu18.jpg
no fit
3p73860887326014VU0409605-1S
Image ml133fu19.jpg
11330
3q285329987326017VU0409609-1S
Image ml133fu20.jpg
8010
3r87205287326013VU0409604-1S
Image ml133fu21.jpg
no fit
3s79192087326015VU0409606-1S
Image ml133fu22.jpg
no fit
3t107595087326019VU0409608-1S
Image ml133fu23.jpg
no fit

From: A potent and selective small molecule Kir2.1 inhibitor

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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