UI Author Year Study Design * Inclusion Exclusion Enrollment Years Trial or Cohort Name Funding Source Extractor
17047087 Stolzenberg-Solomon 2006 Case-cohort study All cases of pancreatic cancer diagnosed between January 1985 and December 2001 were identified through the Finnish Cancer Registry among 29,133 eligible men in south western Finland, ages 50 to 69 years, who smoked at least 5 cigarettes per day, were randomized Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Controls: participants from the same study who were alive at the time the case was diagnosed and free from cancer (except nonmelanoma skin cancer) as of December 2001.
1) history of malignancy other than nonmelanoma cancer of the skin or carcinoma in situ
2) severe angina on exertion,
3) chronicrenal in sufficiency
4) liver cirrhosis, 5) chronic alcoholism, or other medical conditions that might limit long-term participation,
6) anticoagulant therapy
7) used supplements containing vitamin E (> 20 m g/d ), vitamin A (> 20,000 IU/d ), o r β-carotene (> 6 m g/d )
Trial enroll: 1985 – 1988
Cases ascertained:
1985 – 2001
Alpha-Tocopherol, Beta-Carotene Cancer Prevention Stud y NIH GR

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Post hoc analyses of an existing RCT for outcomes that were not planned in the original RCT

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From: Appendix C, Evidence Tables: R-Z

Cover of Vitamin D and Calcium
Vitamin D and Calcium: A Systematic Review of Health Outcomes.
Evidence Reports/Technology Assessments, No. 183.
Chung M, Balk EM, Brendel M, et al.

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