Diagnostic accuracy of IgE compared to an open food challenge for detection of wheat allergy

StudyPopulation testedPrevalenceDiagnostic accuracy for wheatComments
Positive test on challengeImmediate reactionDelayed reactionCombined immediate & delayedSensitivity (%)Specificity (%)PPV (%)NPV (%)
Varjonen 1995180

34 children aged ‘under 1 year’ to 11 years with severe and extensive atopic eczema suspected of food allergy.

(24 underwent food challenge)
63%33%66%NR93567883IgE (CAP RAST) to wheat, rye, barley, oats and gluten. A level of more than 0.5ku/l was reported to be considered positive. However in the diagnostic accuracy tale a level of more than 5.5ku/l was quoted.

It is assumed that diagnostic accuracy relates to any reaction.

NR=not reported

From: Evidence tables

Cover of Atopic Eczema in Children
Atopic Eczema in Children: Management of Atopic Eczema in Children from Birth up to the Age of 12 Years.
NICE Clinical Guidelines, No. 57.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Dec.
Copyright © 2007, National Collaborating Centre for Women’s and Children’s Health.

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