Diagnostic accuracy of a skin prick test compared to a DBPCFC for detection of soya allergy

StudyPopulation testedPrevalenceDiagnostic accuracy for soyaComments
Positive test on challengeImmediate reactionDelayed reactionCombined immediate & delayedSensitivity (%)Specificity (%)PPV (%)NPV (%)
Roehr 2001165

98 children aged 2 months to 11.2 years with atopic eczema (62% mild, 28% moderate, and 10% severe). Not stated whether they were suspected of having food allergy.55%
(64% milk, 67% egg, 51% wheat, 16% soya)

(placebo challenge results NR)
All atopic eczema
All atopic eczema plus respiratory or gastrointestinal symptoms
50905090Results shown are for any reaction (immediate or delayed)
Sampson 1997167


Related (earlier) publication (including 40 of the children, Sampson 984168)
196 children and adolescents, aged 0.6–17.9 years with atopic eczema, ‘approximately’ 50% of whom also had asthma and allergic rhinitis.
It is not clear whether all were suspected of having food allergy, but some were based on the comments made regarding use of DB and open food challenges.
(50% to milk, 73% egg, 49% peanut, 28% soya, 22% wheat, 55% fish)
Mehl 2006181

437 consecutive referrals for suspected food allergy. Children aged 3 months – 14 years (median=13 months). 90% had AE26% (n=180)
(DB and open challenge)

NR=not reported

From: Evidence tables

Cover of Atopic Eczema in Children
Atopic Eczema in Children: Management of Atopic Eczema in Children from Birth up to the Age of 12 Years.
NICE Clinical Guidelines, No. 57.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Dec.
Copyright © 2007, National Collaborating Centre for Women’s and Children’s Health.

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