Table 7.25Global assessment

Global assessment outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee or hip
Patient’s global assessment of Knee osteoarthritis in the last 24 hours1 MA (Towheed et al. 2006) 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksNS
Patient global assessment of response to therapy (average change from baseline)1 RCT (Altman et al. 2007) (N=483)Paracetamol ER
1950 mg/day vs placebo
Over 12 weeks, end of treatmentp=0.015
Favours paracetamol
Patient global assessment of response to therapy (average change from baseline)1 RCT (Altman et al. 2007) (N=483)Paracetamol ER
1950 mg/day vs placebo
Over 12 weeks, end of treatmentp=0.024
Favours paracetamol

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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