Table 7.22Symptoms: pain

Pain outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee
WOMAC Pain (change from baseline)1 RCT (Herrero-Beaumont et al. 2007) (N=325)Paracetamol vs placebo6 months (end of treatment)NS
Knee or hip
Pain response1 MA (Towheed et al. 2006), 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksRR 8.0, 95% CI 2.08 to 30.73, p=0.002
Favours paracetamol
Pain response1 MA (Towheed et al. 2006), 3 RCTsParacetamol vs placeboRange: 7 days to 12 weeksSMD −0.11, 95% CI −0.22 to −0.01, p=0.03
Favours paracetamol
Pain on motion1 MA (Towheed et al. 2006), 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksRR 3.75, 95% CI 1.48 to 9.52, p=0.005
Favours paracetamol
Day pain1 MA (Towheed et al. 2006), 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksSMD −0.29, 95% CI −0.52 to −0.06, p=0.01
Favours paracetamol
Night pain1 MA (Towheed et al. 2006), 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksSMD −0.28, 95% CI −0.51 to −0.05, p=0.02
Favours paracetamol
MDHAQ VAS pain1 MA (Towheed et al. 2006), 2 RCTsParacetamol vs placeboRange: 7 days to 12 weeksSMD −0.18, 95% CI −0.33 to −0.03, p=0.02
Favours paracetamol
Overall pain1 MA (Towheed et al. 2006), 5 RCTsParacetamol vs placeboRange: 7 days to 12 weeksSMD −0.13, 95% CI −0.22 to −0.04, p=0.005
Favours paracetamol
WOMAC pain; Lequesne pain; pain at rest; pain on passive motion1 MA (Towheed et al. 2006) 1 RCTParacetamol vs placeboRange: 7 days to 12 weeksNS
WOMAC pain (average change from baseline)1 RCT (Altman et al. 2007) (N=483)Paracetamol ER
1950 mg/day vs placebo
Over 12 weeks, end of treatment−26.5 and −19.6 respectively, p=0.012
Favours paracetamol
WOMAC pain (average change from baseline)1 RCT (Altman et al. 2007) (N=483)Paracetamol ER
3900 mg/day vs placebo
Over 12 weeks, end of treatmentNS

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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