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Table 35.2Lack of evidence for molecular mimicry between HSV UL6 peptide and corneal antigen

1. Failure to demonstrate an immune response directed to UL6 peptide after HSV ocular infection Deshpande et al., 2001a
2. Ocular infection with vaccinia virus expressing UL6 fails to induce HSK Deshpande et al., 2001a
3. CD4+ T-cells that are apparently tolerized to molecular mimics are able to induce SK lesions upon adoptive transfer to SCID mice Thomas and Rouse, 1998
4. T-cells extracted from human corneas show no reactivity to HSV UL6 Verjans et al., 1998; Koelle et al., 2000
5. T-cells extracted from human corneas are not reactive to corneal antigens Verjans et al., 1998
6. Variation in clinical presentation of SK is not due to genetic variation in the UL6 epitope Ellison et al., 2003

From: Chapter 35, Immunopathological aspects of HSV infection

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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