Fig. 21.2. Presence of functional antiapoptotic genes in HCMV strains.

Fig. 21.2

Presence of functional antiapoptotic genes in HCMV strains. (top) Depiction of the commonly used laboratory strains AD 169, Towne, and Toledo genomes. Rectangles represent repeated ab - b′a′ sequence flanking the unique long (UL) and the c′a - ac sequences flanking the short (US) genome components. An expansion of the region including nucleotides 47,000–54,000 is depicted with a representation of ORFs (open rectangles) in the UL 36-UL37 region. Splicing patterns relevant to proteins with demonstrated antiapoptotic function are indicated by lines connecting ORFs and polyadenylation sites are indicated by arrowheads. The presence (+) or absence (–) of vICA, gpUL37, gpUL37M, and vMIA in AD 169var ATCC, AD 169var DE, Townevar ATCC, Townevar RIT and Toledo (passage 8) is indicated below the ORF diagram (Dunn et al., 2003; Skaletskaya et al., 2001).

From: Chapter 21, Viral modulation of the host response to infection

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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